Nonaxiality in Infrared Dichroic Ratios of Polytopic Transmembrane Proteins
نویسندگان
چکیده
منابع مشابه
Construction of Defined Polytopic Integral Transmembrane Proteins
Signal and stop transfer sequences are discrete regions within a polypeptide chain able to initiate or terminate translocation of the protein across the membrane of the endoplasmic reticulum. We have investigated the role of these topogenic sequences in the biogenesis of polytopic transmembrane proteins. Plasmids encoding various patterns of well-characterized signal and stop transfer sequences...
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To understand the function of membrane proteins, the knowledge of their structure, especially the knowledge of the position of transmembrane segments (TMSs) and of their membrane topology (i.e., orientation of TMSs across the membrane), is crucial. Since most TMSs of α-type polytopic (i.e., having multiple TMSs) membrane proteins are composed of hydrophobic amino acids, they are usually detecte...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1998
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(98)77519-8